Day 832: Scrapieing the Bottom of the Barrel

If you've heard the wild stories about experimental mRNA vaccines causing cancer and prion disease but brushed them off because the mechanism by which they might have such outrageous effects is unclear, the bad cat has some bad news for you:

a nasty ringer is the emergence of the GGGG quadruplex (made easier by adding more G’s) which can cause neurological disease and bind to prions.

this may actually be quite a lot worse in that it appears that you do not even need a full quadruplex for this to happen. duplexes will do if the protein can fold in such a way as to generate what is effectively a quadruplex binding site and thus based on THIS study, all of these sites can play this role: (i) d(TGGGGT), (ii) r(GGAGGAGGAGGA) and (iii) d(GGAGGAGGAGGA) can serve as a quad.

this appears to facilitate the transition of PrPc into its pathologic isoform.

that’s bad.

If you don't recognize PrPSc in the above, just keep in mind that now is not the time to take up cannibalism. And in the future, avoid new technologies that have gone down in flaming failure with horrific side-effects in every previous trial, but are allegedly working perfectly this time.

Speaking of the trials, Steve Kirsch, not content with breaking the news of all-cause mortality being up for the vaccinated in Britain by their own numbers, has also publicized evidence of what the internet cats call pfraud in the latest data dump: Pfizer fraud? Or just great execution? He waffles on whether what happened in Argentina was actual fraud, but of course there were yet more side effects that never made it onto the label:

Neither Augusto’s pericardial effusion, nor another volunteer’s penile vein thrombosis, appear to have found their way into the reported side effects of this trial.

P.S. Massachusetts cases were up a third of a percentage point today.