Mice latently infected with either murine gammaherpesvirus 68 or murine cytomegalovirus, which are genetically highly similar to the human pathogens Epstein–Barr virus and human cytomegalovirus, respectively, are resistant to infection with the bacterial pathogens Listeria monocytogenes and Yersinia pestis. Latency-induced protection is not antigen specific but involves prolonged production of the antiviral cytokine interferon-gamma and systemic activation of macrophages.
Thursday, May 17, 2007
Herpes vs. Plague
Via Gene Expression: in a letter to Nature, researchers claim that latent herpes infections prompt increased immune response to bacterial infections, including Yersinia pestis.
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