Day 1188: The Vaccines Fail to Work, Bivalent Booster Edition

For the last day of the state of emergency, here's a preprint about the boosters failing to provide any protection against the most current incarnation of COVID they considered. They phrase this in terms of various Omicron variants, but there doesn't seem to be any reason to assume it's about the particular variant rather than the passage of time, as boosting is calculated with a week of immortal time.

Despite the immortal time fallacy, they found that more jabs led to more cases of COVID, and that natural immunity led to less COVID:

The risk of COVID-19 also varied by the number of COVID-19 vaccine doses previously received. The higher the number of vaccines previously received, the higher the risk of contracting COVID-19 (Figure 2).

[...]

The multivariable analysis also found that, the more recent the last prior COVID-19 episode was the lower the risk of COVID-19, and that the greater the number of vaccine doses previously received the higher the risk of COVID-19.

They cite some prior speculation (immune imprinting and IgG4 issues with which PlagueBlog readers are familiar) about the causes of the increase in COVID with more jabs, and even dare to suggest that more jabbing may not actually be helping.